Nanoparticles
Nanoparticle research is an area of intense scientific interest in biomedical, optical, and electronic fields. MP-SPR instruments are designed to measure nanoparticle interactions and provide comprehensive characterization label free.
Drug Delivery Nanoparticles
Nanoparticle development for drug delivery and contrast agents demands a comprehensive understanding of several critical factors: nanoparticle-drug interactions, nanoparticle-target interactions, nanoparticle-live cell interactions, and the controlled release of drugs from the nanoparticle carriers. Each of these aspects plays a crucial role in optimizing therapeutic efficacy and minimizing adverse effects.
MP-SPR technology offers a sophisticated approach to studying these intricate interactions. Unlike traditional methods that often require labels or may alter the properties of nanoparticles, MP-SPR enables label-free measurements, preserving the integrity and functionality of the nanoparticles. This capability is particularly valuable for accurately assessing the kinetics of binding reactions between nanoparticles and their targets or drug molecules.
By leveraging MP-SPR technology, researchers and developers can accelerate the optimization of nanoparticle-based drug delivery systems and contrast agents. Whether investigating new formulations, assessing interaction kinetics, or refining release mechanisms, MP-SPR offers a versatile toolset to advance the field of nanomedicine.
Thorough Characterization of Extracellular Vesicles
Extracellular vesicles (EVs) are extensively studied for their unique characteristics and hold significant potential in various fields such as cancer research and therapy, diagnostic, regenerative medicine, and drug delivery. Characterization and interaction measurements of EVs are crucial parts of the research process.
Read more about extracellular vesicles in our EV page.
Key features of MP-SPR in nanoparticle research:
- Precise size and concentration characterization of extracellular vesicles
- Label-Free Detection maintaining native properties and functionalities of nanoparticles
- High Sensitivity
- Characterization of drug release
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- Real-time kinetic analysis of binding interaction
- Versatility to study various nanoparticle formulations and their interactions under conditions relevant to biological environments.
- Measure corona formation on nanoparticle
- Find the optimal surface modification of nanoparticles
Discover the world of MP-SPR
Selected Application Notes
Frequently asked questions
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How can nanoparticle surface modifications be monitored?
MP-SPR detects changes in optical signals (i.e., change in the local refractive index within the evanescent field at a corresponding laser wavelength) caused by functionalization of nanoparticle surfaces. This ensures successful modification and optimization for specific applications.
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How can nanoparticle aggregation behaviour be studied?
By using MP-SPR tracks refractive index changes resulting from nanoparticle aggregation on surfaces in real-time. This provides insights into aggregation kinetics and stability.
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How can nanoparticle binding strength be quantified?
MP-SPR measures kinetic and affinity constants of nanoparticle binding events. This data is critical for understanding the strength and specificity of interactions.
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Is SPR suitable for analyzing nanoparticle interactions in biological media?
Multi-Parametric SPR monitors nanoparticle interactions in complex biological fluids, such as plasma. Unique PureKineticsTM feature allows for the removal of the media effect visible in the SPR sensograms due to Multi-Parametric data. This helps researchers assess real-world behavior and potential applications.
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How does QCMD help analyze the interaction between nanoparticles and biomolecules?
QCMD provides real-time monitoring of nanoparticle adsorption and binding to biomolecules, offering insights into their interaction dynamics. This data is crucial for designing nanoparticles for drug delivery or diagnostic applications.
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Can QCMD study the mechanical properties of nanoparticle layers?
Yes, QCMD evaluates the viscoelastic properties of nanoparticle layers by analyzing dissipation changes. This helps researchers determine the rigidity, flexibility, and structural integrity of nanoparticle films and their anchors.