Nanoparticles

Nanoparticle research is an area of intense scientific interest in biomedical, optical, and electronic fields. MP-SPR instruments are designed to measure nanoparticle interactions and provide comprehensive characterization label free.

Drug Delivery Nanoparticles

Nanoparticle development for drug delivery and contrast agents demands a comprehensive understanding of several critical factors: nanoparticle-drug interactions, nanoparticle-target interactions, nanoparticle-live cell interactions, and the controlled release of drugs from the nanoparticle carriers. Each of these aspects plays a crucial role in optimizing therapeutic efficacy and minimizing adverse effects.

MP-SPR technology offers a sophisticated approach to studying these intricate interactions. Unlike traditional methods that often require labels or may alter the properties of nanoparticles, MP-SPR enables label-free measurements, preserving the integrity and functionality of the nanoparticles. This capability is particularly valuable for accurately assessing the kinetics of binding reactions between nanoparticles and their targets or drug molecules.

By leveraging MP-SPR technology, researchers and developers can accelerate the optimization of nanoparticle-based drug delivery systems and contrast agents. Whether investigating new formulations, assessing interaction kinetics, or refining release mechanisms, MP-SPR offers a versatile toolset to advance the field of nanomedicine.

Thorough Characterization of Extracellular Vesicles

Extracellular vesicles (EVs) are extensively studied for their unique characteristics and hold significant potential in various fields such as cancer research and therapy, regenerative medicine, and drug delivery. Characterization and interaction measurements of EVs are crucial parts of the research process.

The MP-SPR Extracellular Vesicle Characterization Kit enables precise measurements of EV size and concentration. Its high sensitivity allows for accurate detection of small EVs (30 nm and larger), which are challenging to detect using other methods. In addition to size and concentration, the MP-SPR instrument can measure EV cellular uptake, corona formation affinity, and kinetics—all with a single tool!

Key features of MP-SPR in nanoparticle research:

  • Precise size and concentration characterization of extracellular vesicles
  • Label-Free Detection maintaining native properties and functionalities of nanoparticles
  • High Sensitivity
  • Characterization of drug release
    • Real-time kinetic analysis of binding interaction
  • Versatility to study various nanoparticle formulations and their interactions under conditions relevant to biological environments.
  • Measure corona formation on nanoparticle
  • Find the optimal surface modification of nanoparticles

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Selected Application Notes

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