SPResso Talks 12.10.2026 - Artificial nuclear pore complexes and their design optimization with SPR and QCMD

We’re excited to have Professor Andreas Dahlin from Chalmers University of Technology, Sweden present a webinar titled Artificial nuclear pore complexes and their design optimization with SPR and QCMD.

The nuclear pore complex (NPC) is a large protein assembly that controls transport of macromolecules to or from the nucleus in eukaryotic cells. It is capable of facilitated transport in which “cargo” species can bind to “shuttles”, which specifically translocate the NPC, while the cargo alone cannot pass. In order to better understand the transport mechanism, attempts have been made to reconstruct the NPC transport using synthetic systems (bottom-up). However, it has proven difficult to achieve a functioning shuttle-cargo transport mechanism, in particular with high selectivity. I will present our fully artificial NPCs based on heteromolecular interactions in polymer brushes and how we can mimic facilitated transport of nucleic acids while blocking other molecules, including the same nucleic acid in its free form. In particular, I will show how surface sensitive techniques are critical for optimizing the affinity of the interactions so that the NPCs function as intended.

Date: November 12th, 2026

Time: 9 AM CET

You can register to the webinar here!