AN#179 MP-SPR and QCMD Characterization of Viral Spike Capture on Virus-Mimicking Supported Lipid Bilayers on SiO2
Application Note #179
This application note describes the combined use of MP-SPR and QCMD to validate supported lipid bilayer (SLB) formation on SiO₂ and to quantify immobilization and surface coverage of His-tagged SARS-CoV-2 spike proteins. QCMD confirms bilayer formation, integrity, and binding specificity, while MP-SPR provides quantitative spike surface coverage. Together, these complementary techniques enable robust structural and quantitative characterization of biomimetic membrane platforms.