AN#174 Monitoring Nanoparticle-Biofilm Interactions Using MP-SPR
Application Note #174
Bacterial biofilms contribute to persistent infections, posing a significant challenge in healthcare due to their resistance to antibiotics. Nanoparticles (NPs) have emerged as a promising approach for combating biofilm-related infections by either enhancing drug delivery or possessing intrinsic antibacterial properties. In this study, Multi-Parametric Surface Plasmon Resonance (MP-SPR) was utilized as a label-free, real-time analytical platform to monitor bacterial biofilm formation and evaluate interactions between biofilms and cerium oxide-coated mesoporous silica nanoparticles (CeO2@MSNs) with different surface charges.