In vitro monitoring of drug release kinetics with real-time MP-SPR

Application Note #141

Perphenazine release kinetics from thin polymer films. RLPO polymer films with polyvinylpyrrolidone (PVP) had faster release rate compared to film without PVP. The coloured curves are measured and the black curves are fitted.

A real-time Multi-Parametric Surface Plasmon Resonance (MP-SPR) instrument was used to monitor the release rate of a small molecular weight drug, Perphenazine, from 5 microns thin EUDRAGIT®-based polymer films. Thenrelease kinetics was clearly faster from a film containing a film thickening excipient, Polyvinyl-pyrrolidone (PVP) compared to a film without excipient. MP-SPR results had a good correlation with results of in vitro reference measurements. The MP-SPR experiments revealed additional kinetic information compared to traditional in vitro measurements.

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