In vitro monitoring of drug release kinetics with real-time MP-SPR
Application Note #141
A real-time Multi-Parametric Surface Plasmon Resonance (MP-SPR) instrument was used to monitor the release rate of a small molecular weight drug, Perphenazine, from 5 microns thin EUDRAGIT®-based polymer films. Thenrelease kinetics was clearly faster from a film containing a film thickening excipient, Polyvinyl-pyrrolidone (PVP) compared to a film without excipient. MP-SPR results had a good correlation with results of in vitro reference measurements. The MP-SPR experiments revealed additional kinetic information compared to traditional in vitro measurements.