Drug interaction with cell monolayer measured with MP-SPR

Application Note #137

MDCKII cell monolayer was deposited on a gold sensor slide. Drug interaction with the cell monolayer was measured in constant flow conditions.

Cell monolayer was deposited on a SPR sensor slide. Multi-Parametric Surface Plasmon Resonance (MP-SPR) was used to measure drugs (propranolol and D-mannitol) interaction with the cell monolayer in real time and in controlled flow conditions. It was possible to distinguish between paracellular and transcellular drug absorption routes.

 

Download Application Note in PDF

Recommended instrument for this application

Share

Other articles