Drug interaction with cell monolayer measured with MP-SPR

Application Note #137

MDCKII cell monolayer was deposited on a gold sensor slide. Drug interaction with the cell monolayer was measured in constant flow conditions.

Cell monolayer was deposited on a SPR sensor slide. Multi-Parametric Surface Plasmon Resonance (MP-SPR) was used to measure drugs (propranolol and D-mannitol) interaction with the cell monolayer in real time and in controlled flow conditions. It was possible to distinguish between paracellular and transcellular drug absorption routes.

 

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