Recognition-driven assembly of self-limiting supramolecular protein nanoparticles displaying enzymatic activity

We report the recognition-driven assembly of self-limiting protein nanoparticles displaying enzymatic activity. Solution self-assembly of concanavalin A lectin and glycoenzyme glucose oxidase leads to the spontaneous formation of biocolloids with well-defined dimensions, narrow size distribution and remarkable stability. These biocolloids successfully recognize a glycosylated modified electrode retaining the enzyme activity.

Publication year: 2015
Authors: Piccinini E. a, Pallarola D. a, Battaglini F. b, Azzaroni O. *a

* – Corresponding author
a – Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA) – Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata – CONICET, Suc. 4, CC 16, 1900 La Plata, Argentina
b – INQUIMAE, Departamento de Química Inorgánica, Analítica y Química Física, Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, C1428EHA Buenos Aires, Argentina

Published in: Chemical Communications, 2015, Issue 79, p. 14754-7
DOI: 10.1039/c5cc05837f


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