Rapid and Highly Sensitive Detection of Dopamine Using Conjugated Oxaborole-Based Polymer and Glycopolymer Systems

A conjugated polymer interface consisting of an oxaborole containing polymer and a glycopolymer was used for achieving very high selectivity in dopamine (DA) detection. The optimum binding affinity between the polymers promotes the selectivity to DA through a displacement mechanism while remaining unaffected by other structurally related analogs and saccharide derivatives. Real-time detection of DA with very high selectivity and sensitivity has been demonstrated by immobilizing the polymer conjugates on surface plasmon resonance (SPR) and microcantilever (MCL) sensor platforms. Using the conjugated polymer sensing layer, the SPR biosensor was capable of detecting DA in the concentration range of 1 × 10–9 to 1 × 10–4 mol L–1, whereas the MCL sensor showed a limit of detection (LOD) of 5 × 10–11 mol L–1. We find that the sensing mechanism is based on DA-induced reversible swelling of the conjugated polymer layer and this allows regeneration and reuse of the sensor multiple times. Also, we conclude that SPR is a suitable sensor platform for DA in-line detection at clinical level considering the detection time and stability, whereas MCL can achieve a much lower LOD.

Publication year: 2017
Authors: Jiang K., Wang Y., Thaku G., Kotsuchibashi Y., Naicker S., Narain R., Thundat T.

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2 V4, Canada

Published in: ACS Applied Materials and Interfaces, 2017, Vol. 9 (18), p. 15225–15231
DOI: 10.1021/acsami.7b04178


biosensor detection based on swelling of conjugated polymers dopamine (DA) detection polymer interface very high selectivity and sensitivity wide detection range (concentration range) studied


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