Poly(l-lactide-co-2-(2-methoxyethoxy)ethyl methacrylate): A biodegradable polymer with protein resistance

We have synthesized poly(l-lactide-co-2-(2-methoxyethoxy)ethyl methacrylate) (LA-co-MEO2MA) containing both degradable and protein resistant units via hybrid copolymerization with(1-tert-butyl-4,4,4-tris(dimethylamino)-2,2-bis[tris(dimethylamino)phophoranylidenamino]-2Λ5, Λ5-catenadi(phosphazene) (t-BuP4) as the catalyst. Nuclear magnetic resonance (NMR) and differentialscanning calorimetry (DSC) show that LA-co-MEO2MA is a random copolymer. The studies of quartzcrystal microbalance with dissipation (QCM-D) demonstrate that the copolymer enzymatically degrades much faster than poly(l-lactide) (PLA) homopolymer due to its lower crystallinity. We have also investigated the adsorption of bovine serum albumin (BSA), lysozyme or fibrinogen on a LA-co-MEO2MA surface in real time by use of QCM-D and surface plasmon resonance (SPR). Our studies reveal that the polymer is protein resistant depending on MEO2MA content. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay experiments demonstrate that the polymer has a low cytotoxicity.

Publication year: 2014
Authors: Jinbao Xua (a), Xuelin Fan (b), Jinxian Yang (b), Chunfeng Ma (a),Xiaodong Ye (b), Guangzhao Zhanga,(b)

(a) Faculty of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, PR China
(b) Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemical Physics, University of Science and Technology of China,Hefei 230026, PR China

Published in: Colloids and Surfaces B: Biointerfaces, Vol. 116 (2014), p. 531–536
DOI: 10.1016/j.colsurfb.2014.01.047


adsorption bovine serum albumin (BSA) fibrinogen LA-co-MEO2MA surface lysozyme protein-resistant surface QCM-D


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