Degradable Polymer with Protein Resistance in a Marine Environment

Protein resistance is the central issue in marine antibiofouling. We have prepared poly(ε-caprolactone) (PCL)-based polyurethane with 2-(dimethylamino) ethyl methacrylate (DEM) as pendant groups by a combination of the thiol–ene click reaction and the condensation reaction. By the use of quartz crystal microbalance with dissipation (QCM-D) and surface plasmon resonance (SPR), we have investigated the adsorption of fibrinogen, bovine serum albumin (BSA), and lysozyme on the polymer surface. The polymer exhibits protein resistance in seawater but not in fresh water because DEM pendant groups carry net neutral charges in the former. The evaluation of antibacterial adhesion of the polymer by using Micrococcus luteus demonstrates that the polymer can effectively inhibit the settlement of marine bacteria. Our studies also show that the polymer is degradable in marine environments.

Publication year: 2015
Authors: Ma J1, Ma C*1, and Zhang G*1,2

1 Faculty of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, PR China

Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, PR China

Published in: Langmuir, 2015, Vol. 31 [23], p. 6471–6478
DOI: 10.1021/acs.langmuir.5b01720


antibacterial polymer surface antifouling surface protein adsorption protein resistance


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