A Surface Plasmon Resonance Histamine Sensor Based on an Electropolymerized Molecularly Imprinted Polymer (E-MIP)

In this paper, histamine sensing by surface plasmon resonance (SPR) spectroscopy using an electropolymerized molecularly imprinted polymer (E-MIP) of functionalized polyterthiophene and histamine is reported. The MIP histamine sensor showed good linear relationship (R2 = 0.995) between the SPR angle shift and the logarithm of histamine concentration, ranging from 15 – 500 μg/mL, with a limit of detection (LOD) of 2.0 μg/mL and a calibration sensitivity of 44.6 m° per log μg/mL histamine. Results also showed higher binding affinity of histamine for the MIP sensor than for the non-imprinted (NIP) sensor indicating excellent specificity. Moreover, the selectivity of the MIP histamine sensor against some of its structural analogues was demonstrated.

Publication year: 2017
Authors: Hubilla F.A.D., Mabilangan A.I., Advincula R.C., del Mundo F.R.

Institute of Chemistry, University of the Philippines – Diliman, Quezon City, 1101 Philippines

Published in: MATEC Web of Conferences, Vol. 95, 2017
DOI: 10.1051/matecconf/20179502006


binding of structural analogues (L-histidine biosensor cadaverine electropolymerized polymer histamine release histamine sensing MIP sensor molecularly imprinted polymers non-imprinted polymer (NIP) putrescine) sensor selectivity


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